ONASSIS CARDIAC SURGERY CENTER
“Since heart disease is the main cause of morbidity and mortality in smokers, with 40% of deaths in smokers due to coronary artery disease alone, the research team decided to perform the first clinical study of the acute effects of electronic cigarettes on cardiac function.”
According to Dr. Farsalinos,
“It [electronic cigarettes] is the only available product that deals with both the chemical (nicotine delivery) and psychological (inhaling and exhaling ‘smoke’, holding it, etc) addiction to smoking, laboratory analyses indicate that it is significantly less toxic and our study has shown no significant defects in cardiac function after acute use.” [emphasis added]
Findings were presented at the European Society of Cardiology annual congress  in Amsterdam:
INHALATION TOXICOLOGY – Onassis Cardiac Surgery Center
“This is the first study that has ever evaluated the toxicity of electronic cigarette vapor. After 24 hours exposure to tobacco smoke from one cigarette, only 5.7% of the cells survived. In comparison, 20 of the electronic cigarette samples were virtually non-toxic (more than 70% survival) and only one sample showed mild cytotoxicity (51% survival). According to the study results, the worst-performing liquid had 795% higher cell survival relative to tobacco smoke. ‘The results are even more impressive when you consider that we compared one tobacco cigarette with electronic cigarette vapor equivalent to 3 cigarettes’, Dr Farsalinos stated.”
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Comparison of the Cytotoxic Potential of Cigarette Smoke and Electronic Cigarette Vapour Extract on Cultured Myocardial Cells
“This study indicates that some EC samples have cytotoxic properties on cultured cardiomyoblasts, associated with the production process and materials used in flavourings. However, all EC [electronic cigarettes] vapour extracts were significantly less cytotoxic compared to CS [cigarette smoke] extract”
“Researchers at the University of Catania closely monitored and followed 300 smokers during the course of 2 years. Before participating in the study, all 300 smokers agreed to give electronic cigarettes a try. The University wanted to determine the effect e-cigs had on smokers by monitoring their reactions. It’s no secret that thousands of people make the switch from cigarettes to e-cigs each year, but there’s very little clinical data revealing actual statistics, and this is why the University set out on this path.
Another key point of the study that’s worth mentioning is that 4% of those 300 participants quite smoking after trying e-cigs without any nicotine. It’s unclear to researchers what’s causing these smokers to quit without nicotine, but some believe it’s related to the oral fixation of placing a device that looks almost identical to a cigarette up to your lips. “Unlike nicotine gum and patches, e-cigs provide the same habitual movements and motion as smoking a traditional cigarette. Users are able to satisfy those same habitual cravings by using an e-cig rather than smoking a cigarette.”
“‘I think the main message of the study is that we can use these products as an extraordinary tobacco control tool,” Dr. Riccardo Polosa, the new study’s senior author from the University of Catania, told Reuters Health.”’
The entire study can be viewed at Plosone.org
Drexel University School of Public Health
“A study just released by Professor Igor Burstyn, Drexel University School of Public Health, confirms that chemicals in electronic cigarettes (e-cigarettes) pose no health concern for users or bystanders. This is the first definitive study of e-cigarette chemistry and finds that there are no health concerns based on generally accepted exposure limits.”
“By reviewing over 9,000 observations about the chemistry of the vapor and the liquid in e-cigarettes, Dr. Burstyn was able to determine that the levels of contaminants e-cigarette users are exposed to are insignificant, far below levels that would pose any health risk. Additionally, there is no health risk to bystanders. Proposals to ban e-cigarettes in places where smoking is banned have been based on concern there is a potential risk to bystanders, but the study shows there is no concern.”
The entire study can be viewed at Drexel University
University of Hawaii Cancer Center
“More than 1,500 smokers from different ethnic backgrounds were surveyed. Researchers found 13% of them turned to electronic smoking devices to try to kick their habit.
‘We found that people who had used other nicotine replacement therapy that had been approved by the FDA – they were two to four times more likely to have tried electronic cigarettes to quick smoking,’ said Dr. Pallav Pokhrel.”
A online version, published ahead of the print American Journal of Public Health, can be viewed through this link.
Journal of the American Medical Association
“Dr. Neal Benowitz, who served on the FDA’s Tobacco Products Scientific advisory committee, co-authored a July 15 report on e-cigs posted on the Journal of the American Medical Association’s website.”
“Benowitz said e-cigs ‘likely pose less direct hazard to the individual smoker than tobacco cigarettes and might help smokers quit smoking or reduce harm by smoking fewer tobacco cigarettes.”’
–Winston-Salem Journal July 28, 2013
Fraunhofer Institute for Wood Research WKI in Braunschweig
“In general, the emissions of VOCs and ultrafine particles when smoking an e-cigarette were lower than the equivalent emissions from a standard cigarette”, said Schripp
“Additionally, the researcher and his colleagues were unable to find any formaldehyde emissions from the e-cigarette. Regular cigarettes, on the other hand, surpassed the guideline value of 0.1 ppm (parts per million) for indoor air quality under the given test requirements. Vaporized propylene glycol was given off from both tobacco cigarettes and e-cigarettes. Pulmonologists are afraid this solubilizing agent can bother the airways when inhaled in big quantities.”
Source: Medical News Today (December 8, 2012).
American Journal of Health Behavior
“A new study being published in the American Journal of Health Behavior suggests that electronic cigarettes might encourage hard-core tobacco puffers to significantly cut back on traditional cigarettes, even when they say they don’t want to.
The pilot study found that of 28 adult smokers—none of whom were interested in quitting—25, or nearly 90 percent, reduced their use of tobacco cigarettes during a week in which they smoked e-cigarettes from leading maker NJOY.
Nearly one-third of those smokers cut their tobacco cigarette use in half, and four of the participants told researchers that they were smoking no traditional cigarettes at all by the end of the weeklong trial of NJOY Kings.
Overall, the mean reduction in participants’ cigarettes smoked per day was 39 percent, according to the study.
The research report also found that the e-cig users’ nicotine absorption was comparable to that with nicotine-replacement products approved by the Food and Drug Administration. The report noted that ‘these results suggest that this [NJOY] product delivered enough nicotine to suppress craving.”’